Ccl6
Function
Chemotactic factor that attracts mostly macrophage, but it can also attract B cells, CD4(+) lymphocytes and eosinophils.
Post-translational modifications
The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CL6(22-95) and CCL6(23-95) show increase in CCR1-mediated signaling and chemotaxis assays in vitro.
Sequence Similarities
Belongs to the intercrine beta (chemokine CC) family.
Tissue Specificity
Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
Cellular localization
- Secreted
Alternative names
C10, Scya6, Ccl6, C-C motif chemokine 6, Protein C10, Small-inducible cytokine A6