Ccl9
Function
Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.
Post-translational modifications
The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CCL9(29-101), CCL9(30-101) and CCL9(31-101) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro.
Sequence Similarities
Belongs to the intercrine beta (chemokine CC) family.
Tissue Specificity
Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.
Cellular localization
- Secreted
Alternative names
Mrp2, Scya10, Scya9, Ccl9, C-C motif chemokine 9, CCF18, Macrophage inflammatory protein 1-gamma, Macrophage inflammatory protein-related protein 2, Small-inducible cytokine A9, MIP-1-gamma, MRP-2