CCN2

GeneName

CCN2

Summary

CCN2, also known as connective tissue growth factor (CTGF) or CCN-2, is a 38 kDa secreted protein that plays a pivotal role in the extracellular matrix and is expressed in various tissues, including cartilage and skin. It is involved in multiple biological processes such as angiogenesis, cell adhesion, and tissue homeostasis. CCN2 interacts with heparin, insulin-like growth factors, and integrins, facilitating cell-matrix adhesion and promoting chondrocyte differentiation and proliferation. Its presence in the extracellular space underscores its importance in cellular signalling and tissue development.

Importance

CCN2 is relevant to: - Tissue repair and regeneration through its role in cell migration and adhesion - Developmental biology, particularly in cartilage and lung development - Fibrosis and chronic wound healing due to its involvement in extracellular matrix remodelling - Cancer biology, as it can influence tumour growth and metastasis through angiogenic processes

Top Products

For researchers investigating CCN2, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-CTGF antibody (ab5097), which has garnered 23 citations, reflecting its reliability in Western blotting (WB) and immunocytochemistry (ICC). Additionally, we offer the recombinant antibody, Anti-CTGF antibody [EPR20728] (ab209780), which has been validated in a broader range of applications, including WB, ICC, and immunoprecipitation (IP). This recombinant option has received even more attention, with 29 citations, making it a robust choice for those seeking consistency and versatility in their research on CCN2. The Human CTGF ELISA Kit (ab261851), supported by 7 citations, is an excellent option for researchers looking to accurately measure CCN2 levels in their samples.

Abcam Product Citation Summary

The data indicates that CCN2 is being studied in the context of human colorectal cancer and various human tumour cell lines. The use of Western blotting suggests a focus on protein expression levels, particularly in relation to pathways such as YAP1-mediated transcriptional networks and the Hippo pathway.

Abcam Product Citation Table

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Sequence Similarities

Belongs to the CCN family.

Tissue Specificity

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Secreted

Alternative names

CTGF, HCS24, IGFBP8, CCN2, CCN family member 2, Cellular communication network factor 2, Connective tissue growth factor, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8

Database links

swissprot:P29279 omim:121009 entrezGene:1490

Other research areas

• Neuroscience