Ccn2

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).

Sequence Similarities

Belongs to the CCN family.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Secreted

Alternative names

Ctgf, Ccn2, CCN family member 2, Cellular communication network factor 2, Connective tissue growth factor, Connective tissue growth-related protein

Database links

swissprot:Q9R1E9 entrezGene:64032

Other research areas

• Neuroscience