Ccn2

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).

Sequence Similarities

Belongs to the CCN family.

Tissue Specificity

Testis, spleen, kidney, lung, heart, and brain (lowest level in testis and highest in lung).

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Secreted

Alternative names

betaIG-M2, Ctgf, Fisp-12, Fisp12, Hcs24, Ccn2, CCN family member 2, Cellular communication network factor 2, Connective tissue growth factor, Hypertrophic chondrocyte-specific protein 24, Protein FISP-12

Database links

swissprot:P29268 entrezGene:14219

Other research areas

• Neuroscience