CCNA1

Developmental stage

Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.

Function

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Post-translational modifications

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

Sequence Similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Tissue Specificity

Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Cellular localization

• Nucleus

Alternative names

Cyclin-A1, CCNA1

Database links

swissprot:P78396 omim:604036 omim:123835 swissprot:P20248 entrezGene:890 entrezGene:8900