Cyclin A2

Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level).

Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

Belongs to the cyclin family. Cyclin AB subfamily.

• Nucleus
• Cytoplasm
• Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).

CCN1, CCNA, CCNA2, Cyclin-A2, Cyclin-A, Cyclin A

• entrezGene:983
• entrezGene:890
• entrezGene:1017
• omim:123835
• omim:116953
• omim:116940
• swissprot:P20248
• swissprot:P24941
• swissprot:P06493

Proteins

Oncology

• Epigenetics

48551Da