CCNA2
GeneName
CCNA2
Summary
CCNA2, also known as cyclin A or cyclin A2, is a 49kDa protein that plays a vital role in regulating the cell cycle, particularly the G1/S phase transition and the G2/M transition. It forms complexes with cyclin-dependent kinases (CDK1 and CDK2), facilitating their activity in driving cell division and ensuring proper progression through the cell cycle. CCNA2 is expressed in various tissues, localised in the cytoplasm, nucleoplasm, and at the microtubule organising centre, and is involved in a range of cellular responses to hormonal and growth factor stimuli, as well as in processes like animal organ regeneration and cochlea development.
Importance
CCNA2 is relevant to: - Understanding cell cycle regulation and its implications in cancer biology due to its role in cell division and proliferation - Investigating cellular responses to various stimuli, which can inform therapeutic strategies for metabolic disorders and hormonal imbalances - Exploring its involvement in organ regeneration and developmental biology, providing insights into tissue repair mechanisms - Researching the molecular mechanisms underlying diseases linked to dysregulation of the cell cycle, including various cancers and developmental disorders
Top Products
For researchers investigating CCNA2, we highly recommend the top-selling recombinant antibody, Anti-Cyclin A2 antibody [EPR17351] (ab181591). This well-cited product has garnered 130 citations, reflecting its strong reputation in the field. It has been validated for use in several applications, including Western blotting (WB), immunocytochemistry (ICC), and immunohistochemistry (IHC), making it a versatile choice for your research needs. The recombinant nature of this antibody ensures batch-to-batch consistency, providing reliable results in your experiments. The Recombinant Human Cyclin A2 protein ELISA Kit (ab126696), supported by 1 citation, is an excellent option for researchers looking to accurately measure CCNA2 levels in their samples.
Abcam Product Citation Summary
The data indicates that CCNA2 is frequently studied in the context of various cancers, particularly hepatocellular carcinoma (HCC) and acute myeloid leukaemia (AML). The use of Abcam antibodies in Western blotting across different species, including humans and mice, highlights the importance of CCNA2 in cell cycle regulation and proliferation. Additionally, studies involving miR-34a and lncRNA NR-104098 suggest a regulatory role of CCNA2 in cancer progression and response to treatments.
Abcam Product Citation Table
Developmental stage
Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level).
Function
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Post-translational modifications
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome (PubMed:21596315). Deubiquitinated and stabilized by USP37 enables entry into S phase (PubMed:21596315). Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation (PubMed:31413110).
Sequence Similarities
Belongs to the cyclin family. Cyclin AB subfamily.
Cellular localization
- Nucleus
- Cytoplasm
- Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).
Alternative names
CCN1, CCNA, CCNA2, Cyclin-A2, Cyclin-A, Cyclin A
Database links
swissprot:P20248 entrezGene:983 entrezGene:890 swissprot:P24941 swissprot:P06493 omim:123835 omim:116953 omim:116940 entrezGene:1017
Other research areas
- Epigenetics