CCNB1 phospho S126
Developmental stage
Accumulates steadily during G2 and is abruptly destroyed at mitosis.
Function
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Post-translational modifications
Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132). Deubiquitinated by USP22 during G2/M phase (PubMed:27030811).
Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
Sequence Similarities
Belongs to the cyclin family. Cyclin AB subfamily.
Cellular localization
- Cytoplasm
- Nucleus
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
Alternative names
CCNB, CCNB1, G2/mitotic-specific cyclin-B1
Database links
Other research areas
- Epigenetics