Cyclin B1

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132). Deubiquitinated by USP22 during G2/M phase (PubMed:27030811).

Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.

Belongs to the cyclin family. Cyclin AB subfamily.

• Cytoplasm
• Nucleus
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome

CCNB, CCNB1, G2/mitotic-specific cyclin-B1

• entrezGene:891
• omim:123836
• swissprot:P14635

Proteins

Oncology

• Epigenetics

48337Da