CCNB3
Domain
The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Function
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.
Post-translational modifications
Ubiquitinated (Probable). Ubiquitination leads to its degradation during anaphase entry, after degradation of CCNB1.
Sequence Similarities
Belongs to the cyclin family. Cyclin AB subfamily.
Tissue Specificity
Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues.
Cellular localization
- Nucleus
Alternative names
CYCB3, CCNB3, G2/mitotic-specific cyclin-B3