CCNE1

Function

Essential for the control of the cell cycle at the G1/S (start) transition.

Post-translational modifications

Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.

Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.

Sequence Similarities

Belongs to the cyclin family. Cyclin E subfamily.

Tissue Specificity

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Cellular localization

• Nucleus

Alternative names

CCNE, CCNE1, G1/S-specific cyclin-E1

Database links

swissprot:P24864 omim:123837 entrezGene:898

Other research areas

• Epigenetics