CCNG1
Developmental stage
Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.
Function
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
Sequence Similarities
Belongs to the cyclin family. Cyclin G subfamily.
Tissue Specificity
High levels in skeletal muscle, ovary, kidney and colon.
Cellular localization
- Nucleus
- DNA replication foci after DNA damage.
Alternative names
CCNG, CYCG1, CCNG1, Cyclin-G1, Cyclin-G