Ccr1
Function
Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:9166425). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (By similarity). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4 (PubMed:15831559). Mediates also monocyte migration upon CXCL4 binding (By similarity). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (PubMed:31898284).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CD191, Cmkbr1, Ccr1, C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, Macrophage inflammatory protein 1-alpha receptor, RANTES-R, MIP-1alpha-R