CCR3

Function

Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).

(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

In eosinophils as well as trace amounts in neutrophils and monocytes.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

• C-C chemokine receptor type 3
• C C CKR3
• C-C CKR-3
• CC-CKR-3
• CCR-3
• CCR3
• CKR 3
• CKR3
• Eosinophil eotaxin receptor
• CMKBR3
• CCR3

Database links

• entrezGene:1232
• omim:601268
• swissprot:P51677

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

• Immunology & Infectious Disease

Molecular weight

41044Da