CCR3

Function

Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).

(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

In eosinophils as well as trace amounts in neutrophils and monocytes.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

CD193, CMKBR3, CCR3, C-C chemokine receptor type 3, C C CKR3, C-C CKR-3, CC-CKR-3, CCR-3, CKR 3, CKR3, Eosinophil eotaxin receptor

Database links

swissprot:P51677 entrezGene:1232 omim:601268

Other research areas

• Immunology & Infectious Disease