CCR7

Function

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

• C-C chemokine receptor type 7
• C-C CKR-7
• CC-CKR-7
• CCR-7
• BLR2
• CDw197
• Epstein-Barr virus-induced G-protein coupled receptor 1
• MIP-3 beta receptor
• EBI1
• EBV-induced G-protein coupled receptor 1
• CMKBR7
• EBI1
• CCR7
• EVI1

Database links

• entrezGene:1236
• omim:600242
• swissprot:P32248

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

• Immunology & Infectious Disease

Molecular weight

42874Da