CCT4

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).

Belongs to the TCP-1 chaperonin family.

• Cytoplasm
• Melanosome
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Centrosome
• Cytoplasm
• Cytoskeleton
• Cilium basal body
• Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

CCTD, SRB, CCT4, T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta, Chaperonin containing T-complex polypeptide 1 subunit 4, Stimulator of TAR RNA-binding

• entrezGene:10575
• omim:605142
• swissprot:P50991

Proteins

Neuroscience

57924Da