CCT8
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Sequence Similarities
Belongs to the TCP-1 chaperonin family.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Cilium basal body
Alternative names
C21orf112, CCTQ, KIAA0002, CCT8, T-complex protein 1 subunit theta, TCP-1-theta, CCT-theta, Chaperonin containing T-complex polypeptide 1 subunit 8, Renal carcinoma antigen NY-REN-15