CD180
Function
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
Sequence Similarities
Belongs to the Toll-like receptor family.
Tissue Specificity
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD180, LY64, RP105, CD180 antigen, Lymphocyte antigen 64, Radioprotective 105 kDa protein