Cd180
Function
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
Sequence Similarities
Belongs to the Toll-like receptor family.
Tissue Specificity
B-lymphocytes and spleen. Not detected in thymus, kidney, muscle, heart, brain or liver.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD180, Ly78, Rp105, Cd180, CD180 antigen, Lymphocyte antigen 78, Radioprotective 105 kDa protein, Ly-78