Cd2

Function

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Post-translational modifications

N-glycosylated.

Tissue Specificity

Detected in thymus and spleen.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD2, Ly-37, Cd2, T-cell surface antigen CD2, LFA-2, LFA-3 receptor, Lymphocyte antigen 37, T-cell surface antigen T11/Leu-5

Database links

swissprot:P08920 entrezGene:12481

Other research areas

• Immuno-oncology