CD2

Function

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Tissue Specificity

Expressed in natural killer cells (at protein level).

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD2, SRBC, T-cell surface antigen CD2, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5

Database links

swissprot:P06729 omim:186820 omim:186990 swissprot:P09564 entrezGene:924 entrezGene:914

Other research areas

• Immuno-oncology