Cd200r1

Function

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli.

Sequence Similarities

Belongs to the CD200R family.

Tissue Specificity

Expressed in granulocytes, monocytes, most T-cells and a subset of NK, NKT and B-cells (at protein level). Expressed in the spleen, lung, liver, testis, bone marrow, lymph nodes, spinal cord, kidney, uterus and small intestine. Expressed in mast and dendritic cells. Expressed in the lung of N. brasiliensis-infected mice.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

Mox2r, Ox2r, Cd200r1, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1

Database links

swissprot:Q9ES57 entrezGene:57781

Other research areas

• Immunology & Infectious Disease