CD200R1

Function

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Sequence Similarities

Belongs to the CD200R family.

Tissue Specificity

Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

Cellular localization

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 4
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Secreted
• Isoform 3
• Secreted

Alternative names

CD200R, CRTR2, MOX2R, OX2R, UNQ2522/PRO6015, CD200R1, Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1

Database links

swissprot:Q8TD46 entrezGene:131450 omim:607546

Other research areas

• Immunology & Infectious Disease