Cd207

Domain

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.

Function

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.

Tissue Specificity

Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.

Cellular localization

• Membrane
• Single-pass type II membrane protein
• Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.

Alternative names

CD207, Clec4k, Cd207, C-type lectin domain family 4 member K, Langerin

Database links

swissprot:Q8VBX4 entrezGene:246278

Other research areas

• Immuno-oncology