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Cd207

Domain

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.

Function

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.

Involvement in disease

Birbeck granule deficiency

BIRGD

A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.

None

The disease is caused by variants affecting the gene represented in this entry.

Tissue specificity

Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.

Cellular localization

  • Membrane
  • Single-pass type II membrane protein
  • Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.

Alternative names

  • CLEC4K
  • CLEC4K
  • CD207
  • C-type lectin domain family 4 member K
  • Langerin

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology

Molecular weight

36725Da

We found 16 products in 3 categories

Primary Antibodies

Target

Reactive species

Assay Kits

Target

Reactive species

Proteins & Peptides

Target

Species of origin

Nature