CD24
GeneName
CD24
Summary
CD24, also known as hsa, is a glycosylphosphatidylinositol (GPI)-anchored protein that is predominantly expressed on the surface of various immune cells, including B cells and T cells, as well as in certain epithelial tissues. It is localised to the cell membrane, particularly in membrane rafts, and plays a role in cell-cell adhesion, cell activation, and migration. CD24 is involved in several biological processes, such as the transport of B cell receptors into membrane rafts, regulation of immune responses, and differentiation of podocytes and epithelial cells. Its interactions with protein kinases suggest a role in signalling pathways that modulate cell behaviour and fate.
Importance
CD24 is relevant to: - Immune modulation, particularly in the context of B cell activation and T cell costimulation, impacting adaptive immune responses. - Cancer biology, as it is often overexpressed in various malignancies, influencing tumour progression and metastasis. - Kidney function and disease, due to its role in podocyte differentiation and glomerular health. - Inflammatory responses, where it may regulate cell migration and cytokine signalling, contributing to conditions such as autoimmune diseases.
Top Products
For researchers investigating CD24, we highly recommend the top-selling recombinant antibody, Anti-CD24 antibody [EPR3006(N)] (ab179821). This antibody has been validated for use in Western blotting (WB) and immunoprecipitation (IP), making it a versatile tool for your experiments. With 21 citations, it is well-regarded in the research community, reflecting its reliability and effectiveness in detecting CD24. This recombinant antibody ensures batch-to-batch consistency, providing confidence in your results.
Abcam Product Citation Summary
The data indicates that CD24 is being studied in the context of kidney cells from domestic pigs and human fibroblasts. The research focuses on the role of CD24 in efferocytosis impairment associated with senescent cells, highlighting its potential significance in cellular processes related to ageing and tissue health.
Abcam Product Citation Table
Function
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
Involvement in disease
Multiple sclerosis
MS
A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
None
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Post-translational modifications
Extensively O-glycosylated.
Sequence Similarities
Belongs to the CD24 family.
Tissue Specificity
B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen
Database links
swissprot:P25063 entrezGene:100133941 omim:600074
Other research areas
- Immunology & Infectious Disease