CD27

Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:11062504). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (By similarity). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (PubMed:15723067). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (PubMed:38386557).

Phosphorylated.

N-glycosylated.

O-glycosylated with core 1 or possibly core 8 glycans.

In thymus and spleen, but not in non-lymphoid tissues (PubMed:8384562). Expressed on myeloid progenitor cells (PubMed:15723067).

• Cell membrane
• Single-pass type I membrane protein

CD27, Tnfrsf7, Cd27, CD27 antigen, CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7

• entrezGene:21940
• swissprot:P41272

Proteins

Immunology & Infectious Disease

• Immuno-oncology

28164Da