CD276

Function

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Tissue specificity

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

• CD276 antigen
• 4Ig-B7-H3
• B7 homolog 3
• Costimulatory molecule
• B7-H3
• CD276
• B7H3
• PSEC0249
• UNQ309/PRO352

Database links

• entrezGene:80381
• omim:605715
• swissprot:Q5ZPR3

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

57235Da