Cd276
Developmental stage
Highly expressed in developing bones during embryogenesis and expression increases as osteoblast precursor cells differentiate into mature osteoblasts.
Function
Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.
Sequence Similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD276, B7h3, Cd276, CD276 antigen, B7 homolog 3, Costimulatory molecule, B7-H3