Cd28

Function

Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:7688139). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells.

Post-translational modifications

Phosphorylated by LCK (PubMed:27460989). Dephosphorylated by PTPN11 (By similarity).

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD28, T-cell-specific surface glycoprotein CD28, Cd28

Database links

swissprot:P31041 entrezGene:12487

Other research areas

• Immuno-oncology