CD28

Function

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Post-translational modifications

CD40LG induces tyrosine phosphorylation of isoform 3.

Tissue specificity

Expressed in T-cells and plasma cells, but not in less mature B-cells.

Cellular localization

• Membrane
• Single-pass type I membrane protein
• Isoform 3
• Cell surface

Alternative names

• T-cell-specific surface glycoprotein CD28
• TP44
• CD28

Database links

• entrezGene:940
• omim:186760
• swissprot:P10747

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology

Molecular weight

25066Da