CD302
Developmental stage
Expressed at relatively high levels in fetal lung, liver, spleen and kidney with lower expression levels detected in heart, thymus and brain.
Function
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
Post-translational modifications
May be heterogeneously N-glycosylated in some cell types.
Tissue Specificity
Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Cell projection
- Filopodium
- Cytoplasm
- Cell cortex
- Cell projection
- Microvillus
- Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
Alternative names
CD302, CLEC13A, DCL1, KIAA0022, CD302 antigen, C-type lectin BIMLEC, C-type lectin domain family 13 member A, DEC205-associated C-type lectin 1, Type I transmembrane C-type lectin receptor DCL-1