CD33

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563).

Glycosylated.

Phosphorylation is involved in binding to PTPN6 and PTPN11.

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Expressed on myeloid precursors in the bone marrow. In the peripheral blood, mostly expressed on granulocytes.

• Cell membrane
• Single-pass type I membrane protein

CD33, Siglec3, Cd33, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3

• entrezGene:12489
• swissprot:Q63994

Proteins

Immuno-oncology

• Neuroscience

44824Da