Cd33

Function

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins (PubMed:12773563).

Post-translational modifications

Glycosylated.

Phosphorylation is involved in binding to PTPN6 and PTPN11.

Sequence Similarities

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Tissue Specificity

Expressed on myeloid precursors in the bone marrow. In the peripheral blood, mostly expressed on granulocytes.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD33, Siglec3, Cd33, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3

Database links

swissprot:Q63994 entrezGene:12489

Other research areas

• Neuroscience