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Developmental stage

On early hematopoietic progenitor cells.

Function

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Post-translational modifications

Highly glycosylated.

Phosphorylated on serine residues by PKC.

Sequence similarities

Belongs to the CD34 family.

Tissue specificity

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

CD34, Hematopoietic progenitor cell antigen CD34

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology

Molecular weight

40716Da

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