CD34
GeneName
CD34
Summary
CD34, also known as hematopoietic progenitor cell antigen CD34, is a 41kDa glycoprotein expressed on the surface of hematopoietic stem cells, endothelial cells, and various progenitor cells. It is localised to the plasma membrane and plays a crucial role in cell-cell adhesion and cell-matrix interactions. CD34 is involved in various biological processes such as hematopoiesis, endothelial cell proliferation, and leukocyte migration, and it functions by binding carbohydrates and interacting with other proteins. Additionally, it contributes to the development of glomerular endothelium and plays a role in angiogenesis and tissue homeostasis.
Importance
CD34 is relevant to: - Stem cell research, particularly in the identification and isolation of hematopoietic stem cells for transplantation and regenerative medicine. - Vascular biology, as it is involved in endothelial cell functions and angiogenesis, influencing wound healing and tissue repair. - Immunology, due to its role in leukocyte migration and cell adhesion, impacting immune responses and inflammation. - Developmental biology, as it plays a part in the differentiation and proliferation of various progenitor cells and contributes to organ development.
Top Products
For researchers investigating CD34, we highly recommend the top-selling recombinant antibody, Anti-CD34 antibody [EP373Y] (ab81289). This antibody has garnered 731 citations, reflecting its strong reputation in the field. It is validated for a variety of applications, including flow cytometry (FC), immunohistochemistry (IHC), immunocytochemistry (ICC), western blotting (WB), and immunoprecipitation (IP). The versatility and reliability of this antibody make it an excellent choice for those studying CD34. The PerCP/Cy5.5® Anti-CD34 antibody [581] ELISA Kit (ab157325), supported by 2 citations, is an excellent option for researchers looking to accurately measure CD34 levels in their samples.
Abcam Product Citation Summary
The data indicates that CD34 is widely studied in various human tissues, particularly in the context of cancer, stem cell research, and developmental biology. The use of multiple applications such as immunohistochemistry, flow cytometry, and immunofluorescence highlights its importance in understanding cellular processes related to angiogenesis, tumor proliferation, and hematopoiesis.
Abcam Product Citation Table
Developmental stage
On early hematopoietic progenitor cells.
Function
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Post-translational modifications
Highly glycosylated.
Phosphorylated on serine residues by PKC.
Sequence Similarities
Belongs to the CD34 family.
Tissue Specificity
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD34, Hematopoietic progenitor cell antigen CD34
Database links
swissprot:P28906 entrezGene:947 omim:142230
Other research areas
- Immuno-oncology