Cd40

Function

Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (PubMed:12881420).

Cellular localization

• Isoform I
• Cell membrane
• Single-pass type I membrane protein
• Isoform III
• Cell membrane
• Single-pass type I membrane protein
• Isoform IV
• Cell membrane
• Single-pass type I membrane protein
• Isoform V
• Cell membrane
• Single-pass type I membrane protein
• Isoform II
• Secreted

Alternative names

CD40, Tnfrsf5, Cd40, Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor

Database links

swissprot:P27512 entrezGene:21939

Other research areas

• Immunology & Infectious Disease
• Neuroscience