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Cd40
Function
Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (PubMed:12881420).
Cellular localization
- Isoform I
- Cell membrane
- Single-pass type I membrane protein
- Isoform III
- Cell membrane
- Single-pass type I membrane protein
- Isoform IV
- Cell membrane
- Single-pass type I membrane protein
- Isoform V
- Cell membrane
- Single-pass type I membrane protein
- Isoform II
- Secreted
Alternative names
- Tumor necrosis factor receptor superfamily member 5
- B-cell surface antigen CD40
- Bp50
- CD40L receptor
- Cd40
- Tnfrsf5
Database links
Target type
Proteins
Primary research area
Immuno-oncology
Other research areas
- Immunology & Infectious Disease
- Neuroscience
Molecular weight
32093Da