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CD40
Function
Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).
Involvement in disease
Immunodeficiency with hyper-IgM 3
HIGM3
A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
None
The disease is caused by variants affecting the gene represented in this entry.
Tissue specificity
B-cells and in primary carcinomas.
Cellular localization
- Isoform I
- Cell membrane
- Single-pass type I membrane protein
- Isoform II
- Secreted
Alternative names
- Tumor necrosis factor receptor superfamily member 5
- B-cell surface antigen CD40
- Bp50
- CD40L receptor
- CDw40
- CD40
- TNFRSF5
Database links
Target type
Proteins
Primary research area
Immuno-oncology
Other research areas
- Immunology & Infectious Disease
- Neuroscience
Molecular weight
30619Da