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Cd40lg

Function

Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (PubMed:1374165). Involved in immunoglobulin class switching (PubMed:1374165).

CD40 ligand, soluble form

Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.

Post-translational modifications

The soluble form derives from the membrane form by proteolytic processing.

Sequence similarities

Belongs to the tumor necrosis factor family.

Tissue specificity

Specifically expressed on activated CD4+ T-lymphocytes.

Cellular localization

  • Cell membrane
  • Single-pass type II membrane protein
  • Cell surface
  • CD40 ligand, soluble form
  • Secreted
  • Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Alternative names

  • Cd40l
  • Tnfsf5
  • Tnfsf5
  • Cd40lg
  • Cd40l
  • CD40 ligand
  • CD40-L
  • T-cell antigen Gp39
  • TNF-related activation protein
  • Tumor necrosis factor ligand superfamily member 5
  • TRAP

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

  • Immunology & Infectious Disease

Molecular weight

29370Da

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