CD58

Function

Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

Cellular localization

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD58, LFA3, Lymphocyte function-associated antigen 3, Ag3, Surface glycoprotein LFA-3

Database links

swissprot:P19256 omim:153420 entrezGene:965

Other research areas

• Immunology & Infectious Disease
• Neuroscience