Cd68

Function

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Post-translational modifications

N- and O-glycosylated.

Sequence Similarities

Belongs to the LAMP family.

Tissue Specificity

Expressed in tissue macrophages and to a lesser extent in dendritic cells.

Cellular localization

• Isoform Long
• Endosome membrane
• Single-pass type I membrane protein
• Lysosome membrane
• Single-pass type I membrane protein
• Isoform Short
• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD68, Macrosialin, Cd68

Database links

swissprot:P31996 entrezGene:12514

Other research areas

• Immuno-oncology
• Neuroscience