CD68

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

N- and O-glycosylated.

Belongs to the LAMP family.

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

• Isoform Short
• Cell membrane
• Single-pass type I membrane protein
• Isoform Long
• Endosome membrane
• Single-pass type I membrane protein
• Lysosome membrane
• Single-pass type I membrane protein

CD68, Macrosialin, Gp110

• entrezGene:968
• omim:153634
• swissprot:P34810

Proteins

Immunology & Infectious Disease

• Immuno-oncology
• Neuroscience

37408Da