CD68
GeneName
CD68
Summary
CD68, also known as macrosialin or gp110, is a 37 kDa glycoprotein primarily expressed in macrophages and monocytes. It is localised to various cellular membranes, including the lysosomal membrane and plasma membrane, and plays a role in the phagocytic activity of these immune cells. CD68 is involved in autocrine signalling and participates in the inflammatory response, particularly in response to antigenic stimuli. It also influences the cellular response to lipopolysaccharides and oxidised low-density lipoprotein particles, contributing to the regulation of immune functions and protein localisation within organelles.
Importance
CD68 is relevant to: - Understanding macrophage biology and their role in inflammation and immune responses - Investigating the mechanisms of autocrine signalling in immune cells - Exploring its involvement in diseases characterised by chronic inflammation, such as atherosclerosis and autoimmune disorders - Studying its potential as a biomarker for macrophage activation in various pathological conditions
Top Products
For researchers investigating CD68, we highly recommend the top-selling recombinant antibody, Anti-CD68 antibody [KP1] (ab955). This well-cited antibody has garnered 816 citations, reflecting its strong reputation in the field. It has been validated for use in immunohistochemistry (IHC), immunocytochemistry (ICC), and western blotting (WB), making it a versatile choice for various applications. The recombinant nature of this antibody ensures batch-to-batch consistency, providing reliable results for your research on CD68. The Anti-CD68 ELISA Kit (ab125047), supported by 33 citations, is an excellent option for researchers looking to accurately measure CD68 levels in their samples.
Abcam Product Citation Summary
The data indicates that CD68 antibodies are widely used in various studies related to macrophage activity and inflammation across different species, particularly in human and rat tissues. The applications include immunofluorescence and immunohistochemistry, highlighting the importance of CD68 as a marker for macrophage infiltration in various pathological contexts, such as cancer and tissue injury.
Abcam Product Citation Table
Function
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Post-translational modifications
N- and O-glycosylated.
Sequence Similarities
Belongs to the LAMP family.
Tissue Specificity
Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
Cellular localization
- Isoform Short
- Cell membrane
- Single-pass type I membrane protein
- Isoform Long
- Endosome membrane
- Single-pass type I membrane protein
- Lysosome membrane
- Single-pass type I membrane protein
Alternative names
CD68, Macrosialin, Gp110
Database links
swissprot:P34810 entrezGene:968 omim:153634
Other research areas
- Immuno-oncology
- Neuroscience