CD68

Function

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Post-translational modifications

N- and O-glycosylated.

Sequence similarities

Belongs to the LAMP family.

Tissue specificity

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

Cellular localization

• Isoform Short
• Cell membrane
• Single-pass type I membrane protein
• Isoform Long
• Endosome membrane
• Single-pass type I membrane protein
• Lysosome membrane
• Single-pass type I membrane protein

Alternative names

• Macrosialin
• Gp110
• CD68

Database links

• entrezGene:968
• omim:153634
• swissprot:P34810

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology
• Neuroscience

Molecular weight

37408Da