CD7

Function

Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors (PubMed:7506726). Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1 (PubMed:10652336). In turn, mediates the production of cytokines such as IL-2 (PubMed:1709867). On resting NK-cells, CD7 activation results in a significant induction of interferon-gamma levels (PubMed:7506726).

Tissue Specificity

Expressed on T-cells and natural killer (NK) cells and their precursors.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

CD7, T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41

Database links

swissprot:P09564 swissprot:P15144 entrezGene:945 swissprot:P20138 omim:186820 omim:159590 omim:151530 entrezGene:290 entrezGene:924