CD7

Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors (PubMed:7506726). Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1 (PubMed:10652336). In turn, mediates the production of cytokines such as IL-2 (PubMed:1709867). On resting NK-cells, CD7 activation results in a significant induction of interferon-gamma levels (PubMed:7506726).

Expressed on T-cells and natural killer (NK) cells and their precursors.

• Membrane
• Single-pass type I membrane protein

CD7, T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP41

• entrezGene:945
• entrezGene:290
• entrezGene:924
• omim:186820
• omim:159590
• omim:151530
• swissprot:P09564
• swissprot:P15144
• swissprot:P20138

Proteins

Immuno-oncology

25409Da