CD80
GeneName
CD80
Summary
CD80, also known as BB1 or BB-1, is a 33 kDa glycoprotein expressed on the surface of antigen-presenting cells such as dendritic cells and B cells. It is localised to the plasma membrane and plays a vital role in T cell activation and costimulation by interacting with CD28 and CTLA-4 on T cells. This interaction is crucial for the regulation of immune responses, including the activation and proliferation of T cells, as well as the differentiation of T-helper 1 cells. CD80 also participates in various signalling pathways related to immune responses and cellular responses to stimuli such as lipopolysaccharides.
Importance
CD80 is relevant to: - Immune checkpoint therapy, where its interactions with T cell receptors can influence tumour immunity and the efficacy of immunotherapies - Autoimmune diseases, as it modulates T cell activation and can contribute to pathological immune responses - Vaccine development, given its role in enhancing T cell responses to antigens - Understanding the mechanisms of immune tolerance and regulation, particularly in the context of organ transplantation and chronic infections
Top Products
For researchers investigating CD80, we highly recommend the top-selling recombinant antibody, Anti-CD80 antibody [EPR1157(2)] (ab134120). This antibody has been validated in knockout models, ensuring its reliability in various applications, including flow cytometry (FC), immunohistochemistry (IHC), western blotting (WB), and immunoprecipitation (IP). With 42 citations, it is well-regarded in the research community, making it an excellent choice for those seeking dependable CD80 detection in their studies. The Human CD80 ELISA Kit (B7-1) (ab256392) is a reliable option for researchers looking to measure CD80 levels in their samples.
Abcam Product Citation Summary
The data indicates that CD80 is being studied in the context of macrophage polarization, particularly in human skeletal muscle tissue. This suggests a focus on the immune response and its implications in muscle biology.
Abcam Product Citation Table
Function
Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed:10438913). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (PubMed:12121659). Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (PubMed:36727298). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity).
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Post-translational modifications
Palmitoylated by ZDHHC20; palmitoylation protects CD80 from ubiquitin-mediated degradation, regulating the protein stability, and ensures its accurate plasma membrane localization.
Tissue Specificity
Expressed on activated B-cells, macrophages and dendritic cells.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD80, CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7
Database links
swissprot:P33681 omim:112203 entrezGene:941
Other research areas
- Immuno-oncology