Cd80

Developmental stage

Expressed between 4 and 12 hours post-activation. Protein was detected at cell surface at 24 hours and it's expression was maximal from 48 to 72 hours post-activation.

Function

Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:16339518). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Acts also as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (PubMed:22450810).

Tissue Specificity

Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD80, B7, Cd80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen

Database links

swissprot:Q00609 entrezGene:12519

Other research areas

• Immuno-oncology