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CD93

Function

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Post-translational modifications

N- and O-glycosylated.

Tissue specificity

Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

  • Complement component C1q receptor
  • C1q/MBL/SPA receptor
  • CDw93
  • Complement component 1 q subcomponent receptor 1
  • Matrix-remodeling-associated protein 4
  • C1qR
  • C1qR(p)
  • C1qRp
  • C1QR1
  • MXRA4
  • CD93

Target type

Proteins

Molecular weight

68560Da