CDA
GeneName
CDA
Summary
CDA, also known as cytidine deaminase or CDD, is a 16 kDa enzyme predominantly located in the cytosol and associated with various granule lumens. It catalyses the deamination of cytidine to uridine, playing a pivotal role in pyrimidine metabolism and nucleotide salvage pathways. This enzyme is involved in cell surface receptor signalling and has been implicated in the negative regulation of cell growth and nucleotide metabolism. CDA can also bind zinc ions and exhibit homodimerisation, which may influence its enzymatic activity and interactions with other proteins.
Importance
CDA is relevant to: - Nucleotide metabolism and the regulation of cellular proliferation through its role in cytidine deamination and pyrimidine salvage pathways. - Cancer research, as alterations in CDA activity can affect the sensitivity of cells to certain chemotherapeutic agents. - Immune responses, given its involvement in cellular responses to external stimuli. - Potential therapeutic targets in diseases associated with dysregulated nucleotide metabolism.
Top Products
For researchers investigating CDA, we highly recommend the top-selling recombinant antibody, Anti-CDA antibody [EPR20525] (ab222515). This antibody has been validated in knockout models, ensuring reliable performance in various applications, including Western blotting (WB), immunohistochemistry (IHC), and flow cytometry (FC). With 4 citations, it is gaining recognition in the research community for its effectiveness in detecting CDA. This product is an excellent choice for those seeking consistency and reliability in their experiments.
Abcam Product Citation Summary
The CDA antibody (ab78231) has been utilised in various applications, including Western blotting and immunohistochemistry, specifically in human cells and hematopoietic tumor cell lines. The studies focus on cellular sensitivity to 5-azacytidine (5AC) and the susceptibility to DNA hypomethylating agents, highlighting the relevance of CDA in cancer research and epigenetic therapies.
Abcam Product Citation Table
Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence Similarities
Belongs to the cytidine and deoxycytidylate deaminase family.
Tissue Specificity
Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
Alternative names
CDD, CDA, Cytidine deaminase, Cytidine aminohydrolase