CDC37
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Post-translational modifications
Constitutively sumoylated by UBE2I.
Sequence Similarities
Belongs to the CDC37 family.
Cellular localization
- Cytoplasm
Alternative names
CDC37A, CDC37, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37