CDC37

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

Constitutively sumoylated by UBE2I.

Belongs to the CDC37 family.

• Cytoplasm

CDC37A, CDC37, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37

• entrezGene:11140
• omim:605065
• swissprot:Q16543

Proteins

Oncology

44468Da