CDC6
Function
Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.
Post-translational modifications
Ubiquitinated by the E3 ubiquitin ligase complex SCF(CDC4), DIA2, and TOM1; and targeted to the 26S proteasome for degradation.
Phosphorylated by CDC28. Phosphorylation is a prerequisite to ubiquitination and degradation.
Sequence Similarities
Belongs to the CDC6/cdc18 family.
Cellular localization
- Nucleus
- Chromosome
Alternative names
YJL194W, J0347, CDC6, Cell division control protein 6