CDC7

Function

Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN.

Sequence Similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.

Cellular localization

• Nucleus

Alternative names

CDC7L1, CDC7, Cell division cycle 7-related protein kinase, CDC7-related kinase, HsCdc7, huCdc7

Database links

swissprot:O00311 omim:604281 swissprot:Q9UBU7 entrezGene:10926 entrezGene:8317 omim:603311