CDCA3
Domain
The KEN box is required for the association with the APC/C-Cdh1 complex.
Function
F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Ubiquitinated and degraded by the APC/C-Cdh1 complex.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
C8, GRCC8, TOME1, CDCA3, Cell division cycle-associated protein 3, Gene-rich cluster protein C8, Trigger of mitotic entry protein 1, TOME-1