CDCA7L
Function
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Post-translational modifications
Phosphorylation increases its interaction with PSIP1.
Tissue Specificity
Ubiquitous. Overexpressed in medulloblastoma.
Cellular localization
- Cytoplasm
- Nucleus
- Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Alternative names
HR1, JPO2, R1, CDCA7L, Cell division cycle-associated 7-like protein, Protein JPO2, Transcription factor RAM2